Article
IreB, a Ser/Thr kinase substrate, influences antimicrobial resistance in Enterococcus faecalis.
Antimicrobial agents and chemotherapy - 1 Dec 2013
Hall Cherisse L, Tschannen Michael, Worthey Elizabeth A, Kristich Christopher J
Abstract excerpt
Enterococcus faecalis is a Gram-positive bacterium that is a major cause of hospital-acquired infections, in part due to its intrinsic resistance to cephalosporins. The mechanism that confers intrinsic cephalosporin resistance in enterococci remains incompletely defined. Previously, we have shown that the Ser/Thr protein kinase and phosphatase pair IreK and IreP act antagonistically to regulate cephalosporin...
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