Modulation of Global Transcriptional Regulatory Networks as a Strategy for Increasing Kanamycin Resistance of the Translational Elongation Factor-G Mutants in Escherichia coli.

Abstract excerpt

Evolve and resequence experiments have provided us a tool to understand bacterial adaptation to antibiotics. In our previous work, we used short-term evolution to isolate mutants resistant to the ribosome targeting antibiotic kanamycin, and reported that Escherichia coli develops low cost resistance to kanamycin via different point mutations in the translation Elongation Factor-G (EF-G). Furthermore, we had shown...

Topics

• Adenylate Cyclase Toxin
• Anti-Bacterial Agents
• Bacterial Toxins
• Escherichia coli
• Escherichia coli Proteins
• Gene Expression Regulation, Bacterial