Resistance to beta-lactam antibiotics by re-modelling the active site of an E. coli penicillin-binding protein.

doi:10.1038/318478a0

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Article

Resistance to beta-lactam antibiotics by re-modelling the active site of an E. coli penicillin-binding protein.

Nature - 1 Jan 2000

Hedge P J, Spratt B G

Abstract excerpt

The beta-lactam antibiotics kill bacteria by inhibiting a set of penicillin-binding proteins (PBPs) that catalyse the final stages of peptidoglycan synthesis. In some bacteria the development of intrinsic resistance to beta-lactam antibiotics by the reduction in the affinity of PBPs causes seriou...

Topics

Anti-Bacterial Agents
Bacterial Proteins
Binding Sites
Carboxypeptidases
Carrier Proteins
Drug Resistance, Microbial
Escherichia coli
Hexosyltransferases
Muramoylpentapeptide Carboxypeptidase
Mutation
Penicillin-Binding Proteins
Peptidyl Transferases
beta-Lactams

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