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Article

MurAA is required for intrinsic cephalosporin resistance of Enterococcus faecalis.

Antimicrobial agents and chemotherapy - 1 May 2012

Vesić Dušanka, Kristich Christopher J

Abstract excerpt

Enterococcus faecalis is a low-GC Gram-positive bacterium that is intrinsically resistant to cephalosporins, antibiotics that target cell wall biosynthesis. To probe the mechanistic basis for intrinsic resistance, a library of transposon mutants was screened to identify E. faecalis strains that are highly susceptible to ceftriaxone, revealing a transposon mutant with a disruption in murAA. murAA is predicted to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22290954
DOI: 10.1128/AAC.05984-11
PMCID: PMC3346666

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