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Article

DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI.

Nucleic acids research - 1 May 2012

Sato Koichi, Toda Kazue, Ishiai Masamichi, Takata Minoru, Kurumizaka Hitoshi

Abstract excerpt

FANCI and FANCD2 form a complex, and play essential roles in the repair of interstrand DNA crosslinks (ICLs) by the Fanconi anemia (FA) pathway. FANCD2 is monoubiquitylated by the FA core complex, composed of 10 FA proteins including FANCL as the catalytic E3 subunit. FANCD2 monoubiquitylation can be reconstituted with purified minimal components, such as FANCI, E1, UBE2T (E2) and FANCL (E3) in vitro; however,...

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Source

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Identifiers

PMID: 22287633
DOI: 10.1093/nar/gks053
PMCID: PMC3378891

Genes

FANCD2
FANCI
FANCL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI.PMID 22287633Read ↗

Structural insight into FANCI-FANCD2 monoubiquitination.Semantic proximity Read ↗

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