Article
A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.
Molecular cell - 13 Jul 2012
Yan Zhijiang, Guo Rong, Paramasivam Manikandan, Shen Weiping, Ling Chen, Fox David, Wang Yucai, Oostra Anneke B, Kuehl Julia, Lee Duck-Yeon, Takata Minoru, Hoatlin Maureen E, Schindler Detlev, Joenje Hans, de Winter Johan P, Li Lei, Seidman Michael M, Wang Weidong
Abstract excerpt
The Fanconi anemia (FA) protein network is necessary for repair of DNA interstrand crosslinks (ICLs), but its control mechanism remains unclear. Here we show that the network is regulated by a ubiquitin signaling cascade initiated by RNF8 and its partner, UBC13, and mediated by FAAP20, a component of the FA core complex. FAAP20 preferentially binds the ubiquitin product of RNF8-UBC13, and this ubiquitin-binding...
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