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Article

FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.

Nature structural & molecular biology - 1 Jun 2007

Sims Ashley E, Spiteri Elizabeth, Sims Robert J, Arita Adriana G, Lach Francis P, Landers Thomas, Wurm Melanie, Freund Marcel, Neveling Kornelia, Hanenberg Helmut, Auerbach Arleen D, Huang Tony T

Abstract excerpt

Activation of the Fanconi anemia (FA) DNA damage-response pathway results in the monoubiquitination of FANCD2, which is regulated by the nuclear FA core ubiquitin ligase complex. A FANCD2 protein sequence-based homology search facilitated the discovery of FANCI, a second monoubiquitinated component of the FA pathway. Biallelic mutations in the gene coding for this protein were found in cells from four FA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17460694
DOI: 10.1038/nsmb1252

Genes

FANCD2
FANCI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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