Article
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes.
Nature genetics - 29 Jan 2012
Bonnefond Amélie, Clément Nathalie, Fawcett Katherine, Yengo Loïc, Vaillant Emmanuel, Guillaume Jean-Luc, Dechaume Aurélie, Payne Felicity, Roussel Ronan, Czernichow Sébastien, Hercberg Serge, Hadjadj Samy, Balkau Beverley, Marre Michel, Lantieri Olivier, Langenberg Claudia, Bouatia-Naji Nabila, Charpentier Guillaume, Vaxillaire Martine, Rocheleau Ghislain, Wareham Nicholas J, Sladek Robert, McCarthy Mark I, Dina Christian, Barroso Inês, Jockers Ralf, Froguel Philippe
Abstract excerpt
Genome-wide association studies have revealed that common noncoding variants in MTNR1B (encoding melatonin receptor 1B, also known as MT(2)) increase type 2 diabetes (T2D) risk(1,2). Although the strongest association signal was highly significant (P < 1 × 10(-20)), its contribution to T2D risk was modest (odds ratio (OR) of ∼1.10-1.15)(1-3). We performed large-scale exon resequencing in 7,632 Europeans,...
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