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Article

MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans.

Diabetes - 1 Jun 2010

Andersson Ehm A, Holst Birgitte, Sparsø Thomas, Grarup Niels, Banasik Karina, Holmkvist Johan, Jørgensen Torben, Borch-Johnsen Knut, Egerod Kristoffer L, Lauritzen Torsten, Sørensen Thorkild I A, Bonnefond Amélie, Meyre David, Froguel Philippe, Schwartz Thue W, Pedersen Oluf, Hansen Torben

Abstract excerpt

OBJECTIVE: Common variants in the melatonin receptor type 1B (MTNR1B) locus have been shown to increase fasting plasma glucose (FPG) and the risk of type 2 diabetes. The aims of this study were to evaluate whether nonsynonymous variants in MTNR1B associate with monogenic forms of hyperglycemia, type 2 diabetes, or related metabolic traits. RESEARCH DESIGN AND METHODS: MTNR1B was sequenced in 47 probands with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Melatonin, MT2

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Identifiers

PMID: 20200315
DOI: 10.2337/db09-1757
PMCID: PMC2874716

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MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans.PMID 20200315Read ↗

A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.Semantic proximity Read ↗

A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.Semantic proximity Read ↗

Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort.Semantic proximity Read ↗

Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans.Semantic proximity Read ↗

Variants in MTNR1B influence fasting glucose levels.Semantic proximity Read ↗

Genetic variants in MTNR1B affecting insulin secretion.Semantic proximity Read ↗

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes.Semantic proximity Read ↗

Association between the melatonin receptor 1B gene polymorphism on the risk of type 2 diabetes, impaired glucose regulation: a meta-analysis.Semantic proximity Read ↗

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion.Semantic proximity Read ↗

Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go?Semantic proximity Read ↗

Tired of diabetes genetics? Circadian rhythms and diabetes: the MTNR1B story?Semantic proximity Read ↗

Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function.Semantic proximity Read ↗

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