Article
Differential genetic interactions of yeast stress response MAPK pathways.
Molecular systems biology - 17 Apr 2015
Martin Humberto, Shales Michael, Fernandez-Piñar Pablo, Wei Ping, Molina Maria, Fiedler Dorothea, Shokat Kevan M, Beltrao Pedro, Lim Wendell, Krogan Nevan J
Abstract excerpt
Genetic interaction screens have been applied with great success in several organisms to study gene function and the genetic architecture of the cell. However, most studies have been performed under optimal growth conditions even though many functional interactions are known to occur under specific cellular conditions. In this study, we have performed a large-scale genetic interaction analysis in Saccharomyces...
Topics
- Cell Wall
- Gene Expression Regulation, Fungal
- Gene Regulatory Networks
- Genes, Fungal
- MAP Kinase Signaling System
- Metabolic Networks and Pathways
- Mutation
- Osmotic Pressure
- Oxidative Stress
- Plasmids
- Protein Transport
- Saccharomyces cerevisiae