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Article

Functional analysis of bovine TLR5 and association with IgA responses of cattle following systemic immunisation with H7 flagella

18 Feb 2015

Abstract excerpt

Flagellin subunits are important inducers of host immune responses through activation of TLR5 when extracellular and the inflammasome if cytosolic. Our previous work demonstrated that systemic immunization of cattle with flagella generates systemic and mucosal IgA responses. The IgA response in mice is TLR5-dependent and TLR5 can impact on the general magnitude of the adaptive response. However, due to sequence...

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PMID: 25827709
DOI: 10.1186/s13567-014-0135-2

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