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Article

Polymorphisms in the TLR4 and TLR5 gene are significantly associated with inflammatory bowel disease in German shepherd dogs.

PloS one - 23 Dec 2010

Kathrani Aarti, House Arthur, Catchpole Brian, Murphy Angela, German Alex, Werling Dirk, Allenspach Karin

Abstract excerpt

Inflammatory bowel disease (IBD) is considered to be the most common cause of vomiting and diarrhoea in dogs, and the German shepherd dog (GSD) is particularly susceptible. The exact aetiology of IBD is unknown, however associations have been identified between specific single-nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) and human IBD. However, to date, no genetic studies have been undertaken in...

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Source

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Identifiers

PMID: 21203467
DOI: 10.1371/journal.pone.0015740
PMCID: PMC3009732

Genes

TLR4
TLR5
TLR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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