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Article

Predicting deleterious non-synonymous single nucleotide polymorphisms in signal peptides based on hybrid sequence attributes.

Computational biology and chemistry - 1 Feb 2012

Qin Wenli, Li Yizhou, Li Juan, Yu Lezheng, Wu Di, Jing Runyu, Pu Xuemei, Guo Yanzhi, Li Menglong

Abstract excerpt

Signal peptides play a crucial role in various biological processes, such as localization of cell surface receptors, translocation of secreted proteins and cell-cell communication. However, the amino acid mutation in signal peptides, also called non-synonymous single nucleotide polymorphisms (nsS...

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Identifiers

PMID: 22277674
DOI: 10.1016/j.compbiolchem.2011.12.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22277674-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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