Metastasis is an early event in mouse mammary carcinomas and is associated with cells bearing stem cell markers

Abstract excerpt

INTRODUCTION: It is still uncertain whether metastasis is predominantly an early or late event in tumor progression. The detection of early metastases and cells responsible for the dissemination may therefore have significant clinical implications. METHODS: Lung dissemination and/or metastasis were investigated in mice carrying the polyomavirus middle-T oncogene (PyMT) during different stages of mammary...