Article
MYC is a metastasis gene for non-small-cell lung cancer.
PloS one - 24 Jun 2009
Rapp Ulf R, Korn Christian, Ceteci Fatih, Karreman Christiaan, Luetkenhaus Katharina, Serafin Valentina, Zanucco Emanuele, Castro Inês, Potapenko Tamara
Abstract excerpt
BACKGROUND: Metastasis is a process by which cancer cells learn to form satellite tumors in distant organs and represents the principle cause of death of patients with solid tumors. NSCLC is the most lethal human cancer due to its high rate of metastasis. METHODOLOGY/PRINCIPAL FINDINGS: Lack of a suitable animal model has so far hampered analysis of metastatic progression. We have examined c-MYC for its ability...
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