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Article

Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotype.

PloS one - 1 Jan 2014

Saenz Francisco R, Ory Virginie, AlOtaiby Maram, Rosenfield Sonia, Furlong Mary, Cavalli Luciane R, Johnson Michael D, Liu Xuefeng, Schlegel Richard, Wellstein Anton, Riegel Anna T

Abstract excerpt

Mammary epithelial (ME) cells cultured under conventional conditions senesce after several passages. Here, we demonstrate that mouse ME cells isolated from normal mammary glands or from mouse mammary tumor virus (MMTV)-Neu-induced mammary tumors, can be cultured indefinitely as conditionally reprogrammed cells (CRCs) on irradiated fibroblasts in the presence of the Rho kinase inhibitor Y-27632. Cell surface...

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Identifiers

PMID: 24831228
DOI: 10.1371/journal.pone.0097666
PMCID: PMC4022745

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