Article
Evolutionary analysis of HBV "S" antigen genetic diversity in Iranian blood donors: a nationwide study.
Journal of medical virology - 1 Jan 2014
Pourkarim Mahmoud Reza, Sharifi Zohre, Soleimani Ali, Amini-Bavil-Olyaee Samad, Elsadek Fakhr Ahmed, Sijmons Steven, Vercauteren Jurgen, Karimi Gharib, Lemey Philippe, Maes Piet, Alavian Seyed Moayed, Van Ranst Marc
Abstract excerpt
The genetic diversity of the HBV S gene has a significant impact on the prophylaxis and treatment of hepatitis B infection. The effect of selective pressure on this genetic alteration has not yet been studied in Iranian blood donors. To explore HBV evolution and to analyze the effects and patterns of hepatitis B surface antigen (HBsAg) mutations on blood screening assays, 358 Iranian blood donors diagnosed as...
Topics
- Adolescent
- Adult
- Blood Donors
- Carrier State
- Cluster Analysis
- Cross-Sectional Studies
- DNA, Viral
- Enzyme-Linked Immunosorbent Assay
- Evolution, Molecular
- Female
- Genetic Variation
- Genotype
- Hepatitis B