Article
[Analysis on mutation of S gene and P gene of hepatitis B virus in two counties of Sichuan Province].
Zhongguo yi miao he mian yi - 1 Feb 2009
Tong Wen-Bin, He Ji-Lan, Sun Li
Abstract excerpt
OBJECTIVE: To analyze HBV S gene/P gene mutation in 2 counties (districts) of Sichuan province. METHODS: HBV DNA were extracted from sera positive both for HBsAg and HBeAg. After PCR and nucleotide sequencing, nucleotide/amino acid mutation in S and P gene were compared and analyzed. RESULTS: Of 47 serum samples from patients with chronic HBV infection, amino acid mutation in 'a' determinant occurred in 12...
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