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[Analysis on mutation of S gene and P gene of hepatitis B virus in two counties of Sichuan Province].

Zhongguo yi miao he mian yi - 1 Feb 2009

Tong Wen-Bin, He Ji-Lan, Sun Li

Abstract excerpt

OBJECTIVE: To analyze HBV S gene/P gene mutation in 2 counties (districts) of Sichuan province. METHODS: HBV DNA were extracted from sera positive both for HBsAg and HBeAg. After PCR and nucleotide sequencing, nucleotide/amino acid mutation in S and P gene were compared and analyzed. RESULTS: Of 47 serum samples from patients with chronic HBV infection, amino acid mutation in 'a' determinant occurred in 12...

Topics

Amino Acid Sequence
China
Gene Products, pol
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B virus
Humans
Molecular Sequence Data
Mutation
Sequence Alignment

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PMID: 20077675

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