Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HERC6 Is the Main E3 Ligase for Global ISG15 Conjugation in Mouse Cells

17 Jan 2012

Abstract excerpt

Type I interferon (IFN) stimulates expression and conjugation of the ubiquitin-like modifier IFN-stimulated gene 15 (ISG15), thereby restricting replication of a wide variety of viruses. Conjugation of ISG15 is critical for its antiviral activity in mice. HECT domain and RCC1-like domain containing protein 5 (HerC5) mediates global ISGylation in human cells, whereas its closest relative, HerC6, does not. So far,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Immune Response and Inflammation
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22272257
DOI: 10.1371/journal.pone.0029870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HERC6 Is the Main E3 Ligase for Global ISG15 Conjugation in Mouse CellsPMID 22272257Read ↗

HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune ResponseSemantic proximity Read ↗

Rapid evolution of mammalian HERC6 and independent duplication of a chimeric HERC5/6 gene in rodents and bats suggest an overlooked role of HERCs in antiviral innate immunitySemantic proximity Read ↗

Species-Specific Antagonism of Host ISGylation by the Influenza B Virus NS1 ProteinSemantic proximity Read ↗

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis virusesSemantic proximity Read ↗

ISG15 Arg151 and the ISG15-Conjugating Enzyme UbE1L Are Important for Innate Immune Control of Sindbis VirusSemantic proximity Read ↗

Novel Mode of ISG15-Mediated Protection against Influenza A Virus and Sendai Virus in MiceSemantic proximity Read ↗

The diverse repertoire of ISG15: more intricate than initially thoughtSemantic proximity Read ↗

ISG15 driven cellular responses to virus infectionSemantic proximity Read ↗

Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus RegulatorsSemantic proximity Read ↗

Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 PathwaySemantic proximity Read ↗

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewSemantic proximity Read ↗

ISG-15, beyond its functions in the cell: a mini reviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.