Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ISG15 Arg151 and the ISG15-Conjugating Enzyme UbE1L Are Important for Innate Immune Control of Sindbis Virus

11 Dec 2008

Abstract excerpt

Interferon (IFN)-stimulated gene 15 (ISG15) is a ubiquitin-like molecule that conjugates to target proteins via a C-terminal LRLRGG motif and has antiviral function in vivo. We used structural modeling to predict human ISG15 (hISG15) residues important for interacting with its E1 enzyme, UbE1L. Kinetic analysis revealed that mutation of arginine 153 to alanine (R153A) ablated hISG15-hUbE1L binding and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytokine Signaling Pathways and Interactions
Share to Immunotherapy and Immune Responses
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19073728
DOI: 10.1128/jvi.01590-08

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ISG15 Arg151 and the ISG15-Conjugating Enzyme UbE1L Are Important for Innate Immune Control of Sindbis VirusPMID 19073728Read ↗

IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis virusesSemantic proximity Read ↗

Novel Mode of ISG15-Mediated Protection against Influenza A Virus and Sendai Virus in MiceSemantic proximity Read ↗

Identification of Interferon-Stimulated Gene 15 as an Antiviral Molecule during Sindbis Virus Infection In VivoSemantic proximity Read ↗

ISGylation in Innate Antiviral Immunity and Pathogen Defense Responses: A ReviewSemantic proximity Read ↗

ISG15 driven cellular responses to virus infectionSemantic proximity Read ↗

Insights into the ISG15 transfer cascade by the UBE1L activating enzymeSemantic proximity Read ↗

HERC5 and the ISGylation Pathway: Critical Modulators of the Antiviral Immune ResponseSemantic proximity Read ↗

ISG15: A link between innate immune signaling, DNA replication, and genome stabilitySemantic proximity Read ↗

The diverse repertoire of ISG15: more intricate than initially thoughtSemantic proximity Read ↗

Species-Specific Antagonism of Host ISGylation by the Influenza B Virus NS1 ProteinSemantic proximity Read ↗

Mice lacking the ISG15 E1 enzyme UbE1L demonstrate increased susceptibility to both mouse-adapted and non-mouse-adapted influenza B virus infection.Semantic proximity Read ↗

Consecutive Inhibition of ISG15 Expression and ISGylation by Cytomegalovirus RegulatorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.