Article
Replacement of microglial cells using Clodronate liposome and bone marrow transplantation in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis.
Biochemical and biophysical research communications - 10 Feb 2012
Lee Jae Chul, Seong Jinsil, Kim Seung Hyun, Lee Se Jeong, Cho Yu Jin, An Jaeyeol, Nam Do-Hyun, Joo Kyeung Min, Cha Choong Ik
Abstract excerpt
Disease progression of amyotrophic lateral sclerosis (ALS) is partially mediated by the toxic microenvironment established by microglia. In the present study, we used SOD1G93A transgenic mice as an in vivo ALS model and replaced microglia expressing mutant SOD1 (mSOD1) with microglia expressing w...
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