Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease.

International journal of immunogenetics - 1 Jun 2012

Polgar N, Csongei V, Szabo M, Zambo V, Melegh B I, Sumegi K, Nagy G, Tulassay Z, Melegh B

Abstract excerpt

Genome-wide association studies identified many loci associated with the two forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC). Components of the interleukin-23 signalling pathway, such as IL23R, JAK2 and STAT3, have been implicated in both diseases. In addition, emerging evidence supports the role of IL23-driven Th17 cells in inflammation. Here, we studied the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colitis, Ulcerative
Share to Crohn Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Hungary

Share to Inflammatory Bowel Diseases

Share to Janus Kinase 2

Share to Logistic Models

Share to STAT3 Transcription Factor

Source

Identifiers

PMID: 22269120
DOI: 10.1111/j.1744-313X.2012.01084.x

Genes

STAT3
JAK2
CCR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease.PMID 22269120Read ↗

Investigation of IL23R, JAK2, and STAT3 gene polymorphisms and gene-gene interactions in Crohn's disease and ulcerative colitis in a Turkish population.Semantic proximity Read ↗

Susceptibility to ulcerative colitis in Hungarian patients determined by gene-gene interactions.Semantic proximity Read ↗

Polymorphisms of interleukin-23 receptor in patients with inflammatory bowel disease in a Croatian tertiary center.Semantic proximity Read ↗

Polymorphisms in the Toll-Like Receptor and the IL-23/IL-17 Pathways Were Associated with Susceptibility to Inflammatory Bowel Disease in a Danish Cohort.Semantic proximity Read ↗

Analysis of the association of single nucleotide polymorphisms of interleukin-23 receptor (IL-23R) and inflammatory bowel disease in a Chinese Han cohort.Semantic proximity Read ↗

Novel genetic risk markers for ulcerative colitis in the IL2/IL21 region are in epistasis with IL23R and suggest a common genetic background for ulcerative colitis and celiac disease.Semantic proximity Read ↗

Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease.Semantic proximity Read ↗

Genetic association between IL23R rs11209026 and rs10889677 polymorphisms and risk of Crohn's disease and ulcerative colitis: evidence from 41 studies.Semantic proximity Read ↗

rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.Semantic proximity Read ↗

Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.Semantic proximity Read ↗

Targeting the IL-23 Receptor Gene: A Promising Approach in Inflammatory Bowel Disease TreatmentSemantic proximity Read ↗

A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.