Article
Polymorphisms in the Toll-Like Receptor and the IL-23/IL-17 Pathways Were Associated with Susceptibility to Inflammatory Bowel Disease in a Danish Cohort.
PloS one - 1 Jan 2015
Bank Steffen, Andersen Paal Skytt, Burisch Johan, Pedersen Natalia, Roug Stine, Galsgaard Julied, Ydegaard Turino Stine, Brodersen Jacob Broder, Rashid Shaista, Kaiser Rasmussen Britt, Avlund Sara, Bastholm Olesen Thomas, Hoffmann Hans Jürgen, Andersen Nexø Bjørn, Sode Jacob, Vogel Ulla, Andersen Vibeke
Abstract excerpt
BACKGROUND: The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), result from the combined effects of susceptibility genes and environmental factors. Previous studies have shown that polymorphisms in the Toll-like receptor (TLR), the apoptosis, the IL-23/IL-17 and the interferon gamma (IFNG) pathways are associated with risk of both CD and UC. METHODS: Using a candidate gene...
Topics
- Cohort Studies
- Colitis, Ulcerative
- Crohn Disease
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Inflammatory Bowel Diseases