Article

Inactivation of p53 drives breast cancer brain metastasis by altering fatty acid metabolism

2023-12-20

Abstract excerpt

Brain metastasis (BM) is a dire prognosis across cancer types. It is largely unknown why some tumors metastasize to the brain whereas others do not. We analyzed genomic and transcriptional data from clinical samples of breast cancer BM (BCBM) and found that nearly all of them carried p53-inactivating genetic alterations through mutations, copy-number loss, or both. Importantly, p53 pathway activity was already per...

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Literature Corpus work: 2b287ceb-2682-59c0-bbf4-0804e8b862d1
DOI: 10.1101/2023.12.20.572490

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