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Article

The interplay between mutant p53 and the mevalonate pathway.

Cell death and differentiation - 1 Mar 2018

Parrales Alejandro, Thoenen Elizabeth, Iwakuma Tomoo

Abstract excerpt

Missense mutations in the TP53 gene lead to accumulation of dysfunctional TP53 proteins in tumors, showing oncogenic gain-of-function (GOF) activities. Stabilization of mutant TP53 (mutp53) is required for the GOF; however, the mechanisms by which mutp53 promotes cancer progression and how mutp53 stability is regulated are not completely understood. Recent work from our laboratory has identified statins,...

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Share to Tumor Suppressor Protein p53
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29238070
DOI: 10.1038/s41418-017-0026-y
PMCID: PMC5864191

Genes

DNAJA1
MVK
MVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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