Article

Istradefylline, an adenosine A2a receptor antagonist, ameliorates neutrophilic airway inflammation and psoriasis in mice

2021-05-23

Abstract excerpt

<h4>Objective</h4> Extracellular adenosine is produced from secreted ATP by cluster of differentiation (CD)39 and CD73. Both are critical nucleotide metabolizing enzymes of the adenosine generating pathway and are secreted by neuronal or immune cells. Adenosine plays a role in energy processes, neurotransmission, and endogenous regulation of inflammatory responses. Istradefylline is a selective adenosine A2a rece...

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Literature Corpus work: d11b1f2d-5551-5b18-9ba6-098c74125f05
DOI: 10.1101/2021.05.21.445220

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