Article
Preplaque ('preclinical') Aβ-induced inflammation and nerve growth factor deregulation in transgenic models of Alzheimer's disease-like amyloid pathology.
Neuro-degenerative diseases - 1 Jan 2012
Cuello A C, Ferretti M T, Iulita M F
Abstract excerpt
BACKGROUND: Alzheimer's disease (AD) neuropathology likely begins decades before clinical symptoms are manifested. Investigations on the early stages of the amyloid pathology are crucial for the discovery of diagnostic biomarkers or new therapeutic targets. Our transgenic (tg) animal models are most suitable to study early AD pathological events, as the pathology evolves in a well-staged manner, starting with...
Topics
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Animals, Genetically Modified
- Central Nervous System
- Cyclooxygenase 2
- Disease Models, Animal
- Gene Expression Regulation
- Humans
- Inflammation