Article
Transgenic mice as a model of pre-clinical Alzheimer's disease.
Current Alzheimer research - 1 Feb 2011
Ferretti M T, Partridge V, Leon W C, Canneva F, Allard S, Arvanitis D N, Vercauteren F, Houle D, Ducatenzeiler A, Klein W L, Glabe C G, Szyf M, Cuello A C
Abstract excerpt
At diagnosis, Alzheimer's disease (AD) brains are extensively burdened with plaques and tangles and display a degree of synaptic failure most likely beyond therapeutic treatment. It is therefore crucial to identify early pathological events in the progression of the disease. While it is not curre...
Topics
- Age Factors
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Analysis of Variance
- Animals
- Cerebellum
- Cerebral Cortex
- Cognition Disorders
- Disease Models, Animal
- Drug Evaluation, Preclinical
- Gene Expression Regulation
- Hippocampus
- Humans