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Article

Transgenic mice as a model of pre-clinical Alzheimer's disease.

Current Alzheimer research - 1 Feb 2011

Ferretti M T, Partridge V, Leon W C, Canneva F, Allard S, Arvanitis D N, Vercauteren F, Houle D, Ducatenzeiler A, Klein W L, Glabe C G, Szyf M, Cuello A C

Abstract excerpt

At diagnosis, Alzheimer's disease (AD) brains are extensively burdened with plaques and tangles and display a degree of synaptic failure most likely beyond therapeutic treatment. It is therefore crucial to identify early pathological events in the progression of the disease. While it is not currently feasible to identify and study early, pre-clinical stages of AD, transgenic (Tg) models offer a valuable tool in...

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PMID: 21143159
DOI: 10.2174/156720511794604561

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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