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Article

Aging, microglia and cytoskeletal regulation are key factors in the pathological evolution of the APP23 mouse model for Alzheimer's disease.

Biochimica et biophysica acta. Molecular basis of disease - 1 Feb 2017

Janssen Leen, Dubbelaar Marissa L, Holtman Inge R, de Boer-Bergsma Jelkje, Eggen Bart J L, Boddeke Hendrikus W G M, De Deyn Peter P, Van Dam Debby

Abstract excerpt

Aging is the key risk factor for Alzheimer's disease (AD). In addition, the amyloid-beta (Aβ) peptide is considered a critical neurotoxic agent in AD pathology. However, the connection between these factors is unclear. We aimed to provide an extensive characterization of the gene expression profiles of the amyloidosis APP23 model for AD and control mice and to evaluate the effect of aging on these profiles. We...

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PMID: 27838490
DOI: 10.1016/j.bbadis.2016.11.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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