Correlation of HLA-A02* genotype and HLA class I antigen down-regulation with the prognosis of epithelial ovarian cancer.

doi:10.1007/s00262-012-1201-0

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Article

Correlation of HLA-A02* genotype and HLA class I antigen down-regulation with the prognosis of epithelial ovarian cancer.

Cancer immunology, immunotherapy : CII - 1 Aug 2012

Andersson Emilia, Villabona Lisa, Bergfeldt Kjell, Carlson Joseph W, Ferrone Soldano, Kiessling Rolf, Seliger Barbara, Masucci Giuseppe V

Abstract excerpt

BACKGROUND: In recent years, evidence is accumulating that cancer cells develop strategies to escape immune recognition. HLA class I HC down-regulation is one of the most investigated. In addition, different HLA haplotypes are known to correlate to both risk of acquiring diseases and also prognosis in survival of disease or cancer. We have previously shown that patients with serous adenocarcinoma of the ovary in...

Topics

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Carcinoma, Ovarian Epithelial
Down-Regulation
Female
Gene Expression Regulation, Neoplastic
Genotype
HLA-A2 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histocompatibility Antigens Class I

Humans

Immunohistochemistry

Kaplan-Meier Estimate

Middle Aged

Neoplasms, Glandular and Epithelial

Ovarian Neoplasms

Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 22258792
DOI: 10.1007/s00262-012-1201-0
PMCID: PMC8693725

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