Article
Analysis of HLA class I-II haplotype frequency and segregation in a cohort of patients with advanced stage ovarian cancer.
Tissue antigens - 1 Sept 2007
Gamzatova Z, Villabona L, van der Zanden H, Haasnoot G W, Andersson E, Kiessling R, Seliger B, Kanter L, Dalianis T, Bergfeldt K, Masucci G V
Abstract excerpt
In solid tumors, human leucocyte antigen (HLA)-A2 has been suggested to be a risk factor and a negative prognostic factor. The HLA-A2 allele in Scandinavia has a high prevalence; it decreases with latitude and also with ovarian cancer mortality in Europe. Furthermore, an association of the HLA-A2 allele with severe prognosis in serous adenocarcinoma of the ovary in stages III-IV was found. Thirty-two unrelated...
Topics
- Adult
- Aged
- Aged, 80 and over
- Female
- Genetic Predisposition to Disease
- HLA Antigens
- Haplotypes
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Humans
- Middle Aged
- Ovarian Neoplasms