Article
Genetic alterations of HLA-class II in ovarian cancer.
International journal of cancer - 15 Sept 2008
Kübler Kirsten, Arndt Peter F, Wardelmann Eva, Landwehr Christina, Krebs Dieter, Kuhn Walther, van der Ven Katrin
Abstract excerpt
The immune system controls tumor formation through identification and elimination of cellular alterations. Consequently, cancer development in immune competent hosts depends on strategies to evade the immune system. Modulation of tumor antigen-specific immune responses by aberrant expression of HLA-class I and II molecules is well documented in a variety of carcinomas including ovarian cancer. To date, little...
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