HLA traits linked to development of head and neck squamous cell carcinoma affect the progression-free survival of patients.

doi:10.1016/j.oraloncology.2017.04.017

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Article

HLA traits linked to development of head and neck squamous cell carcinoma affect the progression-free survival of patients.

Oral oncology - 1 Jun 2017

Wichmann Gunnar, Herchenhahn Cindy, Boehm Andreas, Mozet Christian, Hofer Mathias, Fischer Milos, Kolb Marlen, Dietz Andreas

Abstract excerpt

BACKGROUND: Personalized medicine and treatment stratification of patients with head and neck squamous cell carcinoma (HNSCC) today mostly ignore genetic heterogeneity in HNSCC but especially the patient's genetic background. We hypothesized that particular human leukocyte antigen (HLA) class I (HLA-A, B, Cw) and II proteins (DR, DQ) confer susceptibility for and influence development of HNSCC and may be...

Topics

Adult
Aged
Alleles
Carcinoma, Squamous Cell
Disease-Free Survival
Female
HLA Antigens
Haplotypes
Head and Neck Neoplasms
Humans
Male
Middle Aged
Risk Factors
Squamous Cell Carcinoma of Head and Neck

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Open in PubMed

Identifiers

PMID: 28559015
DOI: 10.1016/j.oraloncology.2017.04.017

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