Article
Investigating the genetic association between ERAP1 and ankylosing spondylitis.
Human molecular genetics - 1 Nov 2009
Harvey David, Pointon Jennifer J, Evans David M, Karaderi Tugce, Farrar Claire, Appleton Louise H, Sturrock Roger D, Stone Millicent A, Oppermann Udo, Brown Matthew A, Wordsworth B Paul
Abstract excerpt
A strong association between ERAP1 and ankylosing spondylitis (AS) was recently identified by the Wellcome Trust Case Control Consortium and the Australo-Anglo-American Spondylitis Consortium (WTCCC-TASC) study. ERAP1 is highly polymorphic with strong linkage disequilibrium evident across the gene. We therefore conducted a series of experiments to try to identify the primary genetic association(s) with ERAP1. We...
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