Article
Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse.
Nature genetics - 1 Oct 1998
Morgan D, Turnpenny L, Goodship J, Dai W, Majumder K, Matthews L, Gardner A, Schuster G, Vien L, Harrison W, Elder F F, Penman-Splitt M, Overbeek P, Strachan T
Abstract excerpt
Visceral left-right asymmetry occurs in all vertebrates, but the inversion of embryo turning (inv) mouse, which resulted following a random transgene insertion, is the only model in which these asymmetries are consistently reversed. We report positional cloning of the gene underlying this recessive phenotype. Although transgene insertion was accompanied by neighbouring deletion and duplication events, our YAC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.