Article
Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse.
Nature genetics - 1 Oct 1998
Morgan D, Turnpenny L, Goodship J, Dai W, Majumder K, Matthews L, Gardner A, Schuster G, Vien L, Harrison W, Elder F F, Penman-Splitt M, Overbeek P, Strachan T
Abstract excerpt
Visceral left-right asymmetry occurs in all vertebrates, but the inversion of embryo turning (inv) mouse, which resulted following a random transgene insertion, is the only model in which these asymmetries are consistently reversed. We report positional cloning of the gene underlying this recessi...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosomes, Artificial, Yeast
- In Situ Hybridization, Fluorescence
- Mice
- Mice, Mutant Strains
- Mice, Transgenic
- Molecular Sequence Data
- Phenotype
- Proteins
- Sequence Deletion
- Transcription Factors