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Article

Vestibular dysfunction in the epistatic circler mouse is caused by phenotypic interaction of one recessive gene and three modifier genes.

Genome research - 1 Apr 2002

Cryns Kim, Van Spaendonck Michiel P, Flothmann Kris, van Alphen Arjan M, Van De Heyning Paul H, Timmermans Jean-Pierre, De Zeeuw Chris I, Van Camp Guy

Abstract excerpt

Vestibular dysfunction is a frequent clinical problem, leading to dizziness and imbalance. Genes play an important role in its etiology, but the genetics are complex and poorly understood. In this study we have analyzed the complex inheritance pattern in the Epistatic circler mouse, which shows circling behavior indicative of vestibular dysfunction in the mouse. This phenotype exists in a proportion of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11932245
DOI: 10.1101/gr.218402
PMCID: PMC187517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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