Article
The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects.
Developmental biology - 1 Jun 2001
Alavizadeh A, Kiernan A E, Nolan P, Lo C, Steel K P, Bucan M
Abstract excerpt
In a screen for mouse mutations with dominant behavioral anomalies, we identified Wheels, a mutation associated with circling and hyperactivity in heterozygotes and embryonic lethality in homozygotes. Mutant Wheels embryos die at E10.5-E11.5 and exhibit a host of morphological anomalies which include growth retardation and anomalies in vascular and hindbrain development. The latter includes perturbation of...
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