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Article

Mouse models of USH1C and DFNB18: phenotypic and molecular analyses of two new spontaneous mutations of the Ush1c gene.

Human molecular genetics - 1 Dec 2003

Johnson Kenneth R, Gagnon Leona H, Webb Lisa S, Peters Luanne L, Hawes Norman L, Chang Bo, Zheng Qing Yin

Abstract excerpt

We mapped two new recessive mutations causing circling behavior and deafness to the same region on chromosome 7 and showed they are allelic by complementation analysis. One was named 'deaf circler' (allele symbol dfcr) and the other 'deaf circler 2 Jackson' (allele symbol dfcr-2J). Both were shown to be mutations of the Ush1c gene, the mouse ortholog of the gene responsible for human Usher syndrome type IC and...

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Identifiers

PMID: 14519688
DOI: 10.1093/hmg/ddg332
PMCID: PMC2862298

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Source receipt: pubmed, retrieved 7 Sept 2026.

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