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Article

Cdc5-dependent asymmetric localization of bfa1 fine-tunes timely mitotic exit.

PLoS genetics - 1 Jan 2012

Kim Junwon, Luo Guangming, Bahk Young Yil, Song Kiwon

Abstract excerpt

In budding yeast, the major regulator of the mitotic exit network (MEN) is Tem1, a GTPase, which is inhibited by the GTPase-activating protein (GAP), Bfa1/Bub2. Asymmetric Bfa1 localization to the bud-directed spindle pole body (SPB) during metaphase also controls mitotic exit, but the molecular mechanism and function of this localization are not well understood, particularly in unperturbed cells. We identified...

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Identifiers

PMID: 22253605
DOI: 10.1371/journal.pgen.1002450
PMCID: PMC3257293

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Cdc5-dependent asymmetric localization of bfa1 fine-tunes timely mitotic exit.PMID 22253605Read ↗

The C-terminus of Bfa1p in budding yeast is essential to induce mitotic arrest in response to diverse checkpoint-activating signals.Semantic proximity Read ↗

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