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Article

Bfa1 can regulate Tem1 function independently of Bub2 in the mitotic exit network of Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002

Ro Hyeon-Su, Song Sukgil, Lee Kyung S

Abstract excerpt

In budding yeast, exit from mitosis is achieved by inactivation of Cdc28/Clb2 activity. Although it is not clear at present how mitotic exit is triggered, a growing body of evidence suggests that the Tem1 GTPase plays a critical role in mediating this pathway and that Bfa1 and Bub2 constitute a two-component GTPase-activating protein to negatively regulate Tem1. Here, we have demonstrated that introduction of...

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Identifiers

PMID: 11959999
DOI: 10.1073/pnas.062059999
PMCID: PMC122787

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bfa1 can regulate Tem1 function independently of Bub2 in the mitotic exit network of Saccharomyces cerevisiae.PMID 11959999Read ↗

Different levels of Bfa1/Bub2 GAP activity are required to prevent mitotic exit of budding yeast depending on the type of perturbations.Semantic proximity Read ↗

The C-terminus of Bfa1p in budding yeast is essential to induce mitotic arrest in response to diverse checkpoint-activating signals.Semantic proximity Read ↗

The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit.Semantic proximity Read ↗

Cdc5-dependent asymmetric localization of bfa1 fine-tunes timely mitotic exit.Semantic proximity Read ↗

The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis.Semantic proximity Read ↗

Disappearance of the budding yeast Bub2-Bfa1 complex from the mother-bound spindle pole contributes to mitotic exit.Semantic proximity Read ↗

Novel regulation of mitotic exit by the Cdc42 effectors Gic1 and Gic2.Semantic proximity Read ↗

A new function of Skp1 in the mitotic exit of budding yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Multiple telophase arrest bypassed (tab) mutants alleviate the essential requirement for Cdc15 in exit from mitosis in S. cerevisiae.Semantic proximity Read ↗

Nud1p links astral microtubule organization and the control of exit from mitosis.Semantic proximity Read ↗

Saccharomyces cerevisiae BUB2 prevents mitotic exit in response to both spindle and kinetochore damage.Semantic proximity Read ↗

BIM1 encodes a microtubule-binding protein in yeast.Semantic proximity Read ↗

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