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Article

The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit.

Current biology : CB - 2 Nov 2000

Wang Y, Hu F, Elledge S J

Abstract excerpt

At the end of the cell cycle, cyclin-dependent kinase (CDK) activity is inactivated to allow mitotic exit [1]. A protein phosphatase, Cdc14, plays a key role during mitotic exit in budding yeast by activating the Cdh1 component of the anaphase-promoting complex to degrade cyclin B (Clb) and inducing the CDK inhibitor Sic1 to inactivate Cdk1 [2]. To prevent mitotic exit when the cell cycle is arrested at G2/M,...

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PMID: 11084339
DOI: 10.1016/s0960-9822(00)00779-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit.PMID 11084339Read ↗

The C-terminus of Bfa1p in budding yeast is essential to induce mitotic arrest in response to diverse checkpoint-activating signals.Semantic proximity Read ↗

Different levels of Bfa1/Bub2 GAP activity are required to prevent mitotic exit of budding yeast depending on the type of perturbations.Semantic proximity Read ↗

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