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Article

Different levels of Bfa1/Bub2 GAP activity are required to prevent mitotic exit of budding yeast depending on the type of perturbations.

Molecular biology of the cell - 1 Oct 2008

Kim Junwon, Jang Selma Sun, Song Kiwon

Abstract excerpt

In budding yeast, Tem1 is a key regulator of mitotic exit. Bfa1/Bub2 stimulates Tem1 GTPase activity as a GTPase-activating protein (GAP). Lte1 possesses a guanine-nucleotide exchange factor (GEF) domain likely for Tem1. However, recent observations showed that cells may control mitotic exit without either Lte1 or Bfa1/Bub2 GAP activity, obscuring how Tem1 is regulated. Here, we assayed BFA1 mutants with varying...

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Identifiers

PMID: 18667533
DOI: 10.1091/mbc.e08-02-0149
PMCID: PMC2555922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Different levels of Bfa1/Bub2 GAP activity are required to prevent mitotic exit of budding yeast depending on the type of perturbations.PMID 18667533Read ↗

Disappearance of the budding yeast Bub2-Bfa1 complex from the mother-bound spindle pole contributes to mitotic exit.Semantic proximity Read ↗

Bfa1 can regulate Tem1 function independently of Bub2 in the mitotic exit network of Saccharomyces cerevisiae.Semantic proximity Read ↗

The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit.Semantic proximity Read ↗

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Cdc5-dependent asymmetric localization of bfa1 fine-tunes timely mitotic exit.Semantic proximity Read ↗

Septins have a dual role in controlling mitotic exit in budding yeast.Semantic proximity Read ↗

Temporal coupling of spindle disassembly and cytokinesis is disrupted by deletion of LTE1 in budding yeast.Semantic proximity Read ↗

Lte1 promotes mitotic exit by controlling the localization of the spindle position checkpoint kinase Kin4.Semantic proximity Read ↗

Saccharomyces cerevisiae BUB2 prevents mitotic exit in response to both spindle and kinetochore damage.Semantic proximity Read ↗

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