Jointly determining significance levels of primary and replication studies by controlling the false discovery rate in two-stage genome-wide association studies.

Abstract excerpt

In genome-wide association studies, we normally discover associations between genetic variants and diseases/traits in primary studies, and validate the findings in replication studies. We consider the associations identified in both primary and replication studies as true findings. An important question under this two-stage setting is how to determine significance levels in both studies. In traditional methods,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Algorithms
• Share to Bias
• Share to Epidemiologic Research Design