Article
Foxp3 occupancy and regulation of key target genes during T-cell stimulation.
Nature - 22 Feb 2007
Marson Alexander, Kretschmer Karsten, Frampton Garrett M, Jacobsen Elizabeth S, Polansky Julia K, MacIsaac Kenzie D, Levine Stuart S, Fraenkel Ernest, von Boehmer Harald, Young Richard A
Abstract excerpt
Foxp3+CD4+CD25+ regulatory T (T(reg)) cells are essential for the prevention of autoimmunity. T(reg) cells have an attenuated cytokine response to T-cell receptor stimulation, and can suppress the proliferation and effector function of neighbouring T cells. The forkhead transcription factor Foxp3 (forkhead box P3) is selectively expressed in T(reg) cells, is required for T(reg) development and function, and is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.