Article
MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. elegans.
Experimental gerontology - 1 Mar 2012
Hoffmann Michael, Honnen Sebastian, Mayatepek Ertan, Wätjen Wim, Koopman Werner J H, Bossinger Olaf, Distelmaier Felix
Abstract excerpt
Caenorhabditis elegans open reading frame T21C9.1 encodes an uncharacterized protein, which is here named MICS-1 (mitochondrial scaffolding protein-1). It is predicted to be the homolog of human outer mitochondrial membrane protein 25 (OMP25 or synaptojanin-2-binding protein), which is a PDZ domain containing protein with a putative role in cellular stress response pathways. Here, we provide evidence that MICS-1...
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