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Article

Transcriptomic and genetic studies identify NFAT5 as a candidate gene for cocaine dependence.

Translational psychiatry - 27 Oct 2015

Fernàndez-Castillo N, Cabana-Domínguez J, Soriano J, Sànchez-Mora C, Roncero C, Grau-López L, Ros-Cucurull E, Daigre C, van Donkelaar M M J, Franke B, Casas M, Ribasés M, Cormand B

Abstract excerpt

Cocaine reward and reinforcing effects are mediated mainly by dopaminergic neurotransmission. In this study, we aimed at evaluating gene expression changes induced by acute cocaine exposure on SH-SY5Y-differentiated cells, which have been widely used as a dopaminergic neuronal model. Expression changes and a concomitant increase in neuronal activity were observed after a 5 μM cocaine exposure, whereas no changes...

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Identifiers

PMID: 26506053
DOI: 10.1038/tp.2015.158
PMCID: PMC4930134

Genes

NFAT5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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