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Article

Comparative metabolomics reveals biogenesis of ascarosides, a modular library of small-molecule signals in C. elegans.

Journal of the American Chemical Society - 25 Jan 2012

von Reuss Stephan H, Bose Neelanjan, Srinivasan Jagan, Yim Joshua J, Judkins Joshua C, Sternberg Paul W, Schroeder Frank C

Abstract excerpt

In the model organism Caenorhabditis elegans, a family of endogenous small molecules, the ascarosides function as key regulators of developmental timing and behavior that act upstream of conserved signaling pathways. The ascarosides are based on the dideoxysugar ascarylose, which is linked to fatty-acid-like side chains of varying lengths derived from peroxisomal β-oxidation. Despite the importance of ascarosides...

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Identifiers

PMID: 22239548
DOI: 10.1021/ja210202y
PMCID: PMC3269134

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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