Article
Acyl-CoA Oxidases Fine-Tune the Production of Ascaroside Pheromones with Specific Side Chain Lengths.
ACS chemical biology - 20 Apr 2018
Zhang Xinxing, Wang Yuting, Perez David H, Jones Lipinski Rachel A, Butcher Rebecca A
Abstract excerpt
Caenorhabditis elegans produces a complex mixture of ascaroside pheromones to control its development and behavior. Acyl-CoA oxidases, which participate in β-oxidation cycles that shorten the side chains of the ascarosides, regulate the mixture of pheromones produced. Here, we use CRISPR-Cas9 to make specific nonsense and missense mutations in acox genes and determine the effect of these mutations on ascaroside...
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