Article
A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans.
Scientific reports - 25 May 2017
Gao Arwen W, Chatzispyrou Iliana A, Kamble Rashmi, Liu Yasmine J, Herzog Katharina, Smith Reuben L, van Lenthe Henk, Vervaart Martin A T, van Cruchten Arno, Luyf Angela C, van Kampen Antoine, Pras-Raves Mia L, Vaz Frédéric M, Houtkooper Riekelt H
Abstract excerpt
Abnormal nutrient metabolism is a hallmark of aging, and the underlying genetic and nutritional framework is rapidly being uncovered, particularly using C. elegans as a model. However, the direct metabolic consequences of perturbations in life history of C. elegans remain to be clarified. Based on recent advances in the metabolomics field, we optimized and validated a sensitive mass spectrometry (MS) platform for...
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