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Article

Phenotypic and metabonomics studies of FMOs in C. elegans and their roles in lifespan extension.

Metabolomics : Official journal of the Metabolomic Society - 15 Nov 2025

Said Mohamed, Freire Rafael, Cabreiro Filipe, Serrano-Contreras Jose Ivan, Thompson Elinor P, Everett Jeremy R

Abstract excerpt

INTRODUCTION: Flavin-Containing Monooxygenases (FMO) are widely conserved, xenobiotic-detoxifying enzymes whose additional endogenous functions have been revealed in recent studies. Those roles include the regulation of longevity in the model nematode Caenorhabditis elegans. OBJECTIVES: The purpose of this study was to compare aspects of the phenotypes of C. elegans worms with mutations in all fmo genes,...

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Identifiers

PMID: 41241700
DOI: 10.1007/s11306-025-02367-4
PMCID: PMC12619732

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